Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015461 | 0.84 | LMNA (0.57) | MAPTLMNAMAPK1HTTNPC1 | |
| SCHEMBL5682845 | 0.82 | MAPT (0.55) | MAPTLMNAKDM4EKMT2ANPC1 | |
| SCHEMBL8017798 | 0.81 | MAPT (0.71) | MAPTLMNAMAPK1RAF1HTT | |
| SCHEMBL8006281 | 0.80 | MAPT (0.60) | MAPTLMNAKDM4EMAPK1RAF1 | |
| SCHEMBL8015744 | 0.78 | MAPT (0.66) | MAPTLMNAMAPK1HTTKMT2A | |
| SCHEMBL8019313 | 0.76 | MAPT (0.48) | MAPTLMNAKDM4EMAPK1HTT | |
| SCHEMBL8022790 | 0.72 | LMNA (0.50) | MAPTLMNAKDM4EMAPK1HTT | |
| SCHEMBL8006080 | 0.71 | LMNA (0.57) | MAPTLMNAMAPK1HTTNPC1 | |
| SCHEMBL8017392 | 0.71 | MAPT (0.71) | MAPTLMNAMAPK1HTTNPC1 | |
| SCHEMBL8017383 | 0.71 | MAPT (0.71) | MAPTLMNAKDM4EMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |
| EP-0877735-A1 | POLYCYCLIC COMPOUNDS | University of Strathclyde (GB) | 1998-11-18 | — | — | EP | disclosed |
| WO-1997019929-A1 | POLYCYCLIC COMPOUNDS | THE UNIVERSITY OF STRATHCLYDE (GB) | 1997-06-05 | — | — | WO | disclosed |