Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 3/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21609588 | 0.89 | PRKDC (0.42) | PRKDCKCNH2ACHEGRIN1GRIN2B | |
| SCHEMBL8020513 | 0.82 | ACHE (0.36) | PRKDCKCNH2ACHEEGFR | |
| SCHEMBL5208805 | 0.73 | MEN1 (0.41) | — | |
| SCHEMBL31082195 | 0.72 | PLAU (0.35) | KCNH2ACHEEGFR | |
| SCHEMBL8710227 | 0.72 | CYP3A4 (0.36) | ACHEEGFR | |
| SCHEMBL8024858 | 0.72 | ALDH1A1 (0.39) | RXRAGRIN1GRIN2BEGFR | |
| SCHEMBL23293402 | 0.70 | ACHE (0.45) | PRKDCKCNH2ACHES1PR1S1PR3 | |
| SCHEMBL30616739 | 0.70 | ACHE (0.45) | PRKDCKCNH2ACHES1PR1S1PR3 | |
| SCHEMBL8709579 | 0.67 | KDM4E (0.38) | KCNH2 | |
| SCHEMBL22776044 | 0.67 | TRPM8 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802187-B1 | Hydroxypyridine derivatives, their production and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-02-16 | — | — | EP | disclosed |
| US-5891895-A | POTASSIUM CHANNEL MODULATORS; ANGINA PECTORIS; HYPERTENSIVEAGENTS; CARDIOVASCULAR, RESPIRATORY SYSTEM, BRAIN, GASTROINTESTINAL AND UROGENITAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0802187-A1 | Hydroxypyridine derivatives, their production and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-22 | — | — | EP | disclosed |