Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | DRD1 | P21728 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024479 | 0.83 | BRD4 (0.43) | GRM5DRD2DRD1CYP2A6DRD4 | |
| SCHEMBL8025384 | 0.80 | ADRA2A (0.48) | GRM5DRD2DRD1CYP3A4DRD4 | |
| SCHEMBL8022093 | 0.79 | DRD2 (0.37) | GRM5DRD2DRD1DRD4DRD5 | |
| SCHEMBL8024959 | 0.78 | DRD1 (0.46) | GRM5GRM1DRD1CYP3A4 | |
| SCHEMBL8024911 | 0.78 | DRD2 (0.49) | GRM5GRM1DRD2DRD1DRD4 | |
| SCHEMBL8014211 | 0.77 | MAOA (0.44) | CYP2A6CYP2B6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL8028625 | 0.77 | GRM5 (0.38) | GRM5GRM1DRD2DRD1DRD4 | |
| SCHEMBL1011202 | 0.76 | GRM5 (0.37) | GRM5QPCTQPCTLGRM1CYP3A4 | |
| SCHEMBL8030417 | 0.73 | MEN1 (0.44) | DRD2CYP3A4CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL8026766 | 0.73 | HRH4 (0.40) | GRM5GRM1DRD2DRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |