Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21514969 | 0.83 | DRD1 (0.51) | DRD1CYP3A4HTR2BCACNA1BBRD4 | |
| SCHEMBL8022093 | 0.82 | DRD2 (0.37) | DRD1ADRA2AADRA1AGRM5 | |
| SCHEMBL8024911 | 0.81 | DRD2 (0.49) | DRD1ADRA2AADRA1AGRM5GRM1 | |
| SCHEMBL8025384 | 0.80 | ADRA2A (0.48) | DRD1CYP3A4ADRA2AADRA1AGRM5 | |
| SCHEMBL8024458 | 0.78 | DRD2 (0.46) | DRD1BRD4 | |
| SCHEMBL8026577 | 0.78 | GRM5 (0.41) | DRD1CYP3A4GRM5GRM1 | |
| SCHEMBL1013375 | 0.77 | ADRA1A (0.41) | DRD1CYP3A4HTR2BCACNA1BADRA2A | |
| SCHEMBL8024479 | 0.76 | BRD4 (0.43) | DRD1GRM5BRD4 | |
| SCHEMBL8026766 | 0.76 | HRH4 (0.40) | DRD1CYP3A4GRM5GRM1 | |
| SCHEMBL21514982 | 0.75 | DRD1 (0.67) | DRD1CYP3A4HTR2BCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |