Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LGMN | Q99538 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028909 | 0.88 | OPRD1 (0.53) | OPRM1OPRD1MAOASLC6A2SLC6A4 | |
| SCHEMBL1009080 | 0.77 | OPRM1 (0.45) | OPRM1OPRD1MAOASLC6A2SLC6A4 | |
| SCHEMBL1240327 | 0.75 | LGMN (0.46) | OPRM1OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8028683 | 0.74 | TMEM97 (0.56) | MAOASLC6A2SLC6A4SLC6A3TMEM97 | |
| SCHEMBL21646504 | 0.74 | LGMN (0.49) | OPRM1OPRD1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8026503 | 0.74 | MAOA (0.53) | OPRM1OPRD1MAOAMEN1MAPT | |
| SCHEMBL8032013 | 0.73 | MAOA (0.56) | MAOASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8011243 | 0.73 | MAOA (0.56) | OPRM1OPRD1MAOAADRA2AADRA2B | |
| SCHEMBL4752284 | 0.73 | MAOA (0.56) | MAOAMAPTKMT2AALDH1A1KDM4E | |
| SCHEMBL3950020 | 0.73 | MAOA (0.56) | MAOAMAPTKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |