Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027646 | 0.80 | BRD4 (0.38) | HTR1ADRD2GRM5GRM1MAOA | |
| SCHEMBL8028627 | 0.78 | DRD2 (0.55) | HTR1AHTR7DRD2MET | |
| SCHEMBL8026766 | 0.77 | HRH4 (0.40) | DRD2GRM5GRM1MAOACHRM2 | |
| SCHEMBL8031039 | 0.74 | MAOA (0.49) | DRD2METMAOAALOX5 | |
| SCHEMBL8024911 | 0.73 | DRD2 (0.49) | DRD2GRM5GRM1MAOA | |
| SCHEMBL1011582 | 0.73 | HTR1A (0.44) | HTR1AHTR7MAOACHRM5CHRM1 | |
| SCHEMBL8022070 | 0.72 | MAOA (0.41) | HTR1ADRD2MAOA | |
| SCHEMBL8022093 | 0.72 | DRD2 (0.37) | DRD2GRM5MAOA | |
| SCHEMBL8024959 | 0.71 | DRD1 (0.46) | GRM5GRM1 | |
| SCHEMBL8030417 | 0.71 | MEN1 (0.44) | HTR1AHTR7DRD2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |