Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029047 | 0.80 | HTR1A (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8025942 | 0.78 | HTR1A (0.46) | HTR1ADRD2 | |
| SCHEMBL8022070 | 0.75 | MAOA (0.41) | SLC6A2SLC6A4SLC6A3MAOAHTR1A | |
| SCHEMBL1487594 | 0.74 | BRD4 (0.41) | BRD4CREBBPGAAOPRK1CHRM2 | |
| SCHEMBL8026766 | 0.73 | HRH4 (0.40) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8031040 | 0.73 | MAOA (0.46) | GAACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8012555 | 0.73 | UCHL1 (0.45) | BRD4CHRM5SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL8024911 | 0.72 | DRD2 (0.49) | GAAGRM5GRM1MAOADRD2 | |
| SCHEMBL8022093 | 0.71 | DRD2 (0.37) | GRM5MAOADRD2 | |
| SCHEMBL8024959 | 0.70 | DRD1 (0.46) | BRD4GRM5GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |