SCHEMBL8029183

SCHEMBL8029183

CO[Si](CCCNc1ccccc1N)(OC)OC

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.43
ALDH1A1 P00352 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
MAPT P10636 2/20 0.41
HTT P42858 2/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
RECQL P46063 1/20 0.41
MMP14 P50281 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
HDAC6 Q9UBN7 3/20 0.39
HDAC1 Q13547 10/20 0.38
HDAC3 O15379 9/20 0.38
HDAC2 Q92769 3/20 0.37
HDAC4 P56524 2/20 0.37
HDAC7 Q8WUI4 2/20 0.37
HDAC10 Q969S8 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9703627 0.88 CHRM2 (0.49) CHRM2ALDH1A1MAPTHTTKDM4E
SCHEMBL9759440 0.86 CHRM2 (0.39) CHRM2ALDH1A1TDP1MAPTHTT
SCHEMBL9515506 0.84 TLR8 (0.38) CHRM2ALDH1A1TDP1MAPTHTT
SCHEMBL6449056 0.82 MAPT (0.58) CHRM2ALDH1A1MAPTHTTKDM4E
SCHEMBL14682415 0.81 CHRM2 (0.43) CHRM2ALDH1A1MAPTHTTKDM4E
SCHEMBL14682410 0.81 L3MBTL1 (0.49) CHRM2ALDH1A1GAARAB9A
SCHEMBL29008632 0.80 MAPT (0.41) ALDH1A1TDP1MAPTHTTKDM4E
SCHEMBL867417 0.78 PRSS1 (0.47) ALDH1A1TDP1MAPTHTTKDM4E
SCHEMBL215272 0.78 HDAC3 (0.50) CHRM2ALDH1A1MAPTHTTKDM4E
SCHEMBL16798806 0.78 ALDH1A1 (0.56) ALDH1A1MAPTKDM4EMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0368279-B1 Silane coupling agent and glass fiber product for laminates NITTO BOSEKI CO LTD (JP) 2000-03-15 EP disclosed
US-5149839-A Improved impregnation, solvent resistance, heat resistance and low water absoprtion properties NITTO BOSEKI CO., LTD. (JP) 1992-09-22 US disclosed
US-5069971-A With epoxy resins, printed circuits, diaminoalklyalkoxysilane NITTO BOSEKI CO., LTD. (JP) 1991-12-03 US disclosed
US-5010203-A Reacting aminopropylsilane with carbon disulfide; heating DEGUSSA AKTIENGESELLSCHAFT (DE) 1991-04-23 US disclosed
US-4997860-A Amino-substituted silanediol or silanetriol TOSHIBA SILICONE CO., LTD. (JP) 1991-03-05 US disclosed
EP-0368279-A1 Silane coupling agent and glass fiber product for laminates NITTO BOSEKI CO., LTD. (JP) 1990-05-16 EP disclosed