Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720375 | 0.98 | HDAC3 (0.53) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL6247309 | 0.98 | HDAC3 (0.53) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL867417 | 0.95 | PRSS1 (0.47) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL6201094 | 0.90 | MAPT (0.52) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL3870595 | 0.90 | KDM4E (0.59) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL29922455 | 0.90 | TLR8 (0.49) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL1170549 | 0.90 | TLR8 (0.49) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL9320885 | 0.89 | KAT2B (0.54) | HDAC3HDAC1HDAC2NCOR2MAPT | |
| SCHEMBL8082845 | 0.88 | L3MBTL1 (0.48) | HDAC3HDAC1HDAC2NCOR2PRSS1 | |
| SCHEMBL9011310 | 0.88 | L3MBTL1 (0.48) | HDAC3HDAC1HDAC2NCOR2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020202091-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-08 | — | — | WO | disclosed |
| WO-2020202091-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-10-08 | — | — | WO | disclosed |
| EP-2916916-B1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | L'ORÉAL (FR) | 2018-01-10 | — | — | EP | disclosed |
| US-9578944-B2 | Compositions and methods for altering the appearance of hair | L'OREAL (FR) | 2017-02-28 | — | — | US | disclosed |
| US-9565915-B2 | Compositions and methods for altering the appearance of hair | L'OREAL (FR) | 2017-02-14 | — | — | US | disclosed |
| US-9566221-B2 | Methods for altering the color and appearance of hair | L'OREAL (FR) | 2017-02-14 | — | — | US | disclosed |
| US-9474700-B2 | Methods for altering the color and appearance of hair | L'OREAL (FR) | 2016-10-25 | — | — | US | disclosed |
| US-20150290093-A1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | L'OREAL (FR) | 2015-10-15 | — | — | US | disclosed |
| US-20150265513-A1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | L'OREAL (FR) | 2015-09-24 | — | — | US | disclosed |
| EP-2916916-A1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | L'Oréal (FR) | 2015-09-16 | — | — | EP | disclosed |
| WO-2013071194-A1 | COMPOSITIONS AND METHODS FOR ALTERING THE APPEARANCE OF HAIR | L'OREAL (FR) | 2013-05-16 | — | — | WO | disclosed |
| US-8343238-B1 | Process for altering the appearance of hair using a composition containing dyes and non-hydroxide bases | L'OREAL SA. | 2013-01-01 | — | — | US | disclosed |
| US-8088176-B2 | Methods and kits for permanently coloring hair using a developer composition containing an oxidizer composition and a shampoo | L'OREAL (FR) | 2012-01-03 | — | — | US | disclosed |
| US-20110209720-A1 | METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING A DEVELOPER COMPOSITION CONTAINING AN OXIDIZER COMPOSITION AND A SHAMPOO | L'OREAL (FR) | 2011-09-01 | — | — | US | disclosed |
| EP-1091942-B1 | POTASSIUM CHANNEL BLOCKING AGENTS | NEUROSEARCH AS (DK) | 2005-03-30 | — | — | EP | disclosed |
| US-6569880-B2 | Guanidine derivatives | NEUROSEARCH A/S (DK) | 2003-05-27 | — | — | US | disclosed |
| US-20020137784-A1 | Potassium channel blocking agents | NEUROSEARCH A/S | 2002-09-26 | — | — | US | disclosed |
| US-6380180-B1 | BENZIMIDAZOLE COMPOUNDS FOR TREATMENT OF ASTHMA, VASOSPASM, MEMORY LOSS, MIGRAINE AND OTHERS DISEASES ASSOCIATED WITH POTASSIUM CHANNELS | NEUROSEARCH A/S (DK) | 2002-04-30 | — | — | US | disclosed |
| US-20020049246-A1 | Potassium channel blocking agents | NEUROSEARCH A/S | 2002-04-25 | — | — | US | disclosed |
| US-6194447-B1 | ASTHMA, ANTICONVULSANTS, COGNITION ACTIVATORS, BRAIN DISORDERS, PSYCHOLOGICAL DISORDERS, CARDIOVASCULAR DISORDERS,GASTROINTESTINAL DISORDERS | NEUROSEARCH A/S (DK) | 2001-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110209720-A1 | METHODS AND KITS FOR PERMANENTLY COLORING HAIR USING A DEVELOPER COMPOSITION CONTAINING AN OXIDIZER COMPOSITION AND A SHAMPOO | PPOX, SCO2, SDHB | HDAC3 1214/4885HDAC1 863/4885HDAC2 1543/4885 |
| US-20150290093-A1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | TYR, COXFA4L2, MT-CO3 | HDAC3 779/4885HDAC1 318/4885HDAC2 660/4885 |
| US-20150265513-A1 | METHODS FOR ALTERING THE COLOR AND APPEARANCE OF HAIR | COXFA4L2, TYR, COX5A | HDAC3 746/4885HDAC1 388/4885HDAC2 660/4885 |
| US-20020137784-A1 | Potassium channel blocking agents | KCNH2, KCNH3, KCND2 | HDAC3 573/4885HDAC1 843/4885HDAC2 876/4885 |
| US-20020049246-A1 | Potassium channel blocking agents | KCNH2, KCNH3, KCND2 | HDAC3 573/4885HDAC1 843/4885HDAC2 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.