Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 5/20 | 0.42 |
| ▸ | CES1 | P23141 | 5/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45430 | 0.73 | CES2 (0.53) | CES2CES1BCHEDAOCTSL | |
| SCHEMBL78856 | 0.71 | CES2 (0.46) | CES2CES1BCHEDAO | |
| SCHEMBL11355080 | 0.70 | CES2 (0.50) | CES2CES1BCHEDAOCTSL | |
| Ammonia Solution, Strong SCHEMBL3047305 | 0.70 | CES2 (0.50) | CES2CES1BCHEDAOCTSL | |
| SCHEMBL3975406 | 0.70 | CES2 (0.50) | CES2CES1BCHEDAOCTSL | |
| SCHEMBL4461977 | 0.70 | DGAT1 (0.47) | CES2CES1BCHE | |
| SCHEMBL78210 | 0.69 | CA1 (0.43) | CES2CES1 | |
| SCHEMBL331592 | 0.69 | — | — | |
| Hydrazine SCHEMBL3793747 | 0.67 | CES2 (0.48) | CES2CES1BCHEDAO | |
| SCHEMBL5609948 | 0.66 | CES2 (0.32) | CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | claimed |
| US-10730826-B2 | Ketone inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2020-08-04 | — | — | US | claimed |
| EP-3512846-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-24 | — | — | EP | claimed |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-11 | — | — | US | claimed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | claimed |
| EP-1015641-B1 | SIMPLIFIED SEQUENTIAL CHEMILUMINESCENT DETECTION | LUMIGEN INC (US) | 2007-06-13 | — | — | EP | claimed |
| EP-1015641-A4 | SIMPLIFIED SEQUENTIAL CHEMILUMINESCENT DETECTION | LUMIGEN INC (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0938677-A4 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN INC (US) | 2000-09-27 | — | — | EP | claimed |
| EP-1015641-A1 | SIMPLIFIED SEQUENTIAL CHEMILUMINESCENT DETECTION | LUMIGEN, INC. (US) | 2000-07-05 | — | — | EP | claimed |
| US-6068979-A | IMMOBILIZING TARGETS, CONTACTING WITH LABELED SPECIFIC BINDING PARTNERS FOR EACH TARGET, REACTING WITH SUBSTRATE FOR FIRST LABEL, DETECTING, REACTING WITH SUBSTRATE FOR SECOND ENZYME, DETECTING; ELIMINATES NEED FOR STRIPPING/REPROBING | LUMIGEN, INC. (US) | 2000-05-30 | — | — | US | claimed |
| WO-1999054503-B1 | SIMPLIFIED SEQUENTIAL CHEMILUMINESCENT DETECTION | LUMIGEN INC (US) | 1999-11-25 | — | — | WO | claimed |
| WO-1999054503-A1 | SIMPLIFIED SEQUENTIAL CHEMILUMINESCENT DETECTION | LUMIGEN, INC. (US) | 1999-10-28 | — | — | WO | claimed |
| EP-0938677-A1 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN, INC. (US) | 1999-09-01 | — | — | EP | claimed |
| US-5843666-A | Chemiluminescent detection methods using dual enzyer-labeled binding partners | LUMIGEN, INC. (US) | 1998-12-01 | — | — | US | claimed |
| WO-1998021586-A1 | CHEMILUMINESCENT DETECTION METHODS USING DUAL ENZYME-LABELED BINDING PARTNERS | LUMIGEN, INC. (US) | 1998-05-22 | — | — | WO | claimed |
| US-20230395857-A1 | NON-AQUEOUS ELECTROLYTE SOLUTION AND NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY EMPLOYING THE SAME | MITSUBISHI CHEMICAL CORPORATION (JP) | 2023-12-07 | — | — | US | disclosed |
| CN-109983012-B | Ketone inhibitors of lysine gum protease | 莱特豪斯制药公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-1998002741-A1 | QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES | TREGA BIOSCIENCES, INC. (US) | 1998-01-22 | — | — | WO | disclosed |
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | CES2 1035/4885CES1 124/4885BCHE 148/4885 |
| US-10730826-B2 | Ketone inhibitors of lysine gingipain | PHYKPL, ENPEP, PREP | CES2 1035/4885CES1 124/4885BCHE 148/4885 |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | CES2 1035/4885CES1 124/4885BCHE 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.