SCHEMBL78210

SCHEMBL78210

[O]c1c(F)c(F)cc(F)c1F

nearest known ligand 0.43

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
CA4 P22748 2/20 0.43
CA12 O43570 1/20 0.43
CA7 P43166 1/20 0.43
CA13 Q8N1Q1 1/20 0.43
CES2 O00748 3/20 0.41
CES1 P23141 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12817090 0.80 CA1 (0.40) CA1CA2CA4CA12CA7
SCHEMBL7702552 0.72 CA1 (0.43) CA1CA2CA4CA12CA7
SCHEMBL41646 0.72 CA1 (0.43) CA1CA2CA4CA12CA7
SCHEMBL186507 0.71 CES2 (0.48) CA1CA2CA4CA12CA7
SCHEMBL295026 0.71 CA1 (0.38) CA1CA2CA4CA12CA7
Formaldehyde SCHEMBL27280878 0.71 CA1 (0.43) CA1CA2CA4CA12CA7
SCHEMBL23589702 0.69 CA1 (0.41) CA1CA2CA4CA12CA7
SCHEMBL6470270 0.69 CA1 (0.41) CA1CA2CA4CA12CA7
Bromide SCHEMBL6247121 0.69 CA1 (0.41) CA1CA2CA4CA12CA7
SCHEMBL31540317 0.69 CA1 (0.41) CA1CA2CA4CA12CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 364 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118265545-A Asymmetric bisbenzimidazole STING agonist immunoconjugates and uses thereof 博尔特生物治疗药物有限公司 2024-06-28 CN claimed
WO-2024137619-A1 ANTI-CLAUDIN, BIS-BENZIMID AZOLE STING AGONIST IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2024-06-27 WO claimed
US-20240197899-A1 2-AMINO-4-CARBOXAMIDE-BENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2024-06-20 US claimed
WO-2024129956-A1 THIENOAZEPINE IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2024-06-20 WO claimed
EP-4373891-A2 AZAINDOLE CYANINE DYES, USES, AND METHODS OF PREPARATION Life Technologies Corporation (US) 2024-05-29 EP claimed
CN-117794583-A Bisbenzimidazole STING agonist immunoconjugates and uses thereof 博尔特生物治疗药物有限公司 2024-03-29 CN claimed
CN-117529529-A Azaindole cyanine dye, application and preparation method 生命技术公司 2024-02-06 CN claimed
WO-2023225534-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. (US) 2023-11-23 WO claimed
US-20230374045-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS PROTOMER TECHNOLOGIES INC. 2023-11-23 US claimed
US-20230293716-A1 ELASTASE-SUBSTRATE, PEPTIDE LINKER IMMUNOCONJUGATES, AND USES THEREOF BOLT BIOTHERAPEUTICS, INC. (US) 2023-09-21 US claimed
US-20120156140-A1 FLUORESCENT COMPOUNDS DYOMICS GMBH (DE) 2012-06-21 US claimed
US-20100317045-A1 COMPOUNDS USED AS DYES COMPERABLE TO ALEXA FLUOR 350 DYES PIERCE BIOTECHNOLOGY, INC. (US) 2010-12-16 US claimed
EP-1792949-B1 Hydrophilic marker on the basis of diastereomeric cyanines DYOMICS GMBH (DE) 2010-09-08 EP claimed
US-7612091-B2 Caspase inhibitors and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2009-11-03 US claimed
EP-1792949-A2 Hydrophilic marker on the basis of diastereomeric cyanines Dyomics GmbH (DE) 2007-06-06 EP claimed
US-20040192612-A1 Caspase inhibitors and uses thereof VERTEX PHARMACEUTICALS INCORPORATED 2004-09-30 US claimed
US-6084102-A THE OLIGONUCLEOTIDE IS COMPLEMENTARY TO A TARGET SEQUENCE OF SINGLE STRANDED OR DOUBLE STRANDED DNA, RNA OR HYBRIDS AND, WHEN USED AS A PROBE, BINDS MORE STRONGLY BECAUSE OF THE BOUND MINOR GROVE BINDER; MEDICAL DIAGNOSIS; ANTISENSE THERAPY EPOCH PHARMACEUTICALS, INC. (US) 2000-07-04 US claimed
US-6072046-A SELECTIVELY FORM TRIPLEXES WITH A COMPLEMENTARY TARGET SEQUENCE IN DOUBLE-STRANDED DNA AND EFFICIENTLY CROSSLINK WITH BOTH STRANDS; THERAPEUTICS, DIAGNOSTICS, AND GENETIC PROBES EPOCH PHARMACEUTICALS, INC. (US) 2000-06-06 US claimed
WO-2000012523-A1 DIAZIRIDINYL-ARYL AND BIS-[DI(CHLOROETHYL)AMINO]-ARYL OLIGONUCLEOTIDE CONJUGATES AND REAGENTS FOR MAKING THE SAME EPOCH PHARMACEUTICALS, INC. (US) 2000-03-09 WO claimed
US-5746997-A Radiohalogenation of oligonucleotides via trialkylstannylaryl conjugates EPOCH PHARMACEUTICALS, INC. (US) 1998-05-05 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317045-A1 COMPOUNDS USED AS DYES COMPERABLE TO ALEXA FLUOR 350 DYES ACR, RO60, ARF5 CA1 2168/4885CA2 1667/4885CA4 422/4885
US-20120156140-A1 FLUORESCENT COMPOUNDS NCL, FUS, EFTUD2 CA1 3764/4885CA2 4187/4885CA4 2512/4885
US-20230293716-A1 ELASTASE-SUBSTRATE, PEPTIDE LINKER IMMUNOCONJUGATES, AND USES THEREOF SERPINB1, ELANE, CELA1 CA1 1675/4885CA2 3303/4885CA4 1487/4885
US-20040192612-A1 Caspase inhibitors and uses thereof CASP1, CASP3, CASP5 CA1 321/4885CA2 465/4885CA4 1092/4885
US-20240197899-A1 2-AMINO-4-CARBOXAMIDE-BENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF AADAC, BRD4, IDO2 CA1 460/4885CA2 574/4885CA4 276/4885
US-20230374045-A1 AROMATIC BORON-CONTAINING COMPOUNDS AND RELATED INSULIN ANALOGS IAPP, GPR119, INSR CA1 4652/4885CA2 2869/4885CA4 2326/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.