Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | DRD4 | P21917 | 5/20 | 0.35 |
| ▸ | DRD3 | P35462 | 5/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 8/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 8/20 | 0.35 |
| ▸ | RELA | Q04206 | 8/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | BAD | Q92934 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8970254 | 0.98 | DRD2 (0.34) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL3290331 | 0.85 | PRKAB2 (0.41) | TAAR1NOS3NOS1NOS2BCL2L1 | |
| SCHEMBL3290338 | 0.81 | PRKAB2 (0.41) | TAAR1NOS3NOS1NOS2 | |
| SCHEMBL7201732 | 0.78 | NFKB1 (0.33) | DRD2DRD4DRD3NFKB1NFKB2 | |
| Hydrochloric Acid SCHEMBL7207993 | 0.76 | NFKB1 (0.32) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL7203555 | 0.76 | NFKB1 (0.44) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8643128 | 0.74 | DRD2 (0.64) | DRD2DRD4DRD3SLC6A4 | |
| SCHEMBL7394577 | 0.73 | PRKAB2 (0.46) | DRD2DRD3NFKB1NFKB2RELA | |
| SCHEMBL8045126 | 0.73 | NFKB1 (0.62) | NFKB1NFKB2RELASLC6A2SLC6A4 | |
| SCHEMBL10509049 | 0.72 | L3MBTL1 (0.35) | DRD2DRD4DRD3BCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100268-A | MIGRAINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-08 | — | — | US | disclosed |
| US-5824682-A | Vasoconstrictive dihydrobenzopyran derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-10-20 | — | — | US | disclosed |
| EP-0714396-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005383-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | disclosed |