Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051390 | 0.82 | GPR55 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17723376 | 0.82 | ALDH1A1 (0.51) | HTR7ALDH1A1GAAMAPT | |
| SCHEMBL3559049 | 0.79 | PLK1 (0.45) | PFKFB3TNFGRK6SCN1ASCN5A | |
| SCHEMBL3560403 | 0.78 | CSF1R (0.58) | PFKFB3TNFGRK6PLK1 | |
| SCHEMBL13313078 | 0.78 | CSF1R (0.58) | PFKFB3TNFGRK6PLK1 | |
| SCHEMBL8053632 | 0.74 | PFKFB3 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8038839 | 0.74 | NPC1 (0.46) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL8038833 | 0.72 | PDE2A (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15247594 | 0.72 | HDAC4 (0.50) | — | |
| SCHEMBL12411080 | 0.70 | GAA (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |