Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 5/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20022025 | 0.84 | PSEN1 (0.49) | PDE2AHDAC4HDAC1HDAC6PSEN1 | |
| SCHEMBL8051390 | 0.83 | GPR55 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL20021789 | 0.82 | HDAC4 (0.44) | PDE2AHDAC4HDAC1HDAC6PSEN1 | |
| SCHEMBL17723350 | 0.80 | HDAC4 (0.43) | PDE2AHDAC4HDAC1HDAC6PSEN1 | |
| SCHEMBL17723376 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAAMAPTATP1A1ATP1B1 | |
| SCHEMBL8038836 | 0.72 | NPC1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4897243 | 0.72 | CNR2 (0.52) | PDE2ACNR1CNR2MAPTKCNH2 | |
| SCHEMBL12411080 | 0.71 | GAA (0.54) | ALDH1A1GAAMAPT | |
| SCHEMBL28277730 | 0.71 | PDE2A (0.47) | PDE2ACNR1CNR2ALDH1A1 | |
| SCHEMBL21555167 | 0.69 | ENPP2 (0.52) | HDAC4HDAC1HDAC6PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |