Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.43 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.41 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.41 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.41 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.41 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.41 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.41 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.41 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051390 | 0.83 | GPR55 (0.47) | ALDH1A1GAAMAPTATP1A1ATP1B1 | |
| SCHEMBL8038836 | 0.82 | NPC1 (0.48) | ALDH1A1GAAMAPTHTR7 | |
| SCHEMBL8038833 | 0.80 | PDE2A (0.44) | ALDH1A1GAAMAPTATP1A1ATP1B1 | |
| SCHEMBL8038839 | 0.78 | NPC1 (0.46) | ALDH1A1GAAMAPTMAP4K4 | |
| SCHEMBL12411080 | 0.77 | GAA (0.54) | ALDH1A1GAAMAPTLMNAPOLB | |
| SCHEMBL1991252 | 0.73 | CSF1R (0.62) | NUDT1KCNN3KDM4E | |
| SCHEMBL4375466 | 0.73 | HTR7 (0.58) | NUDT1MAP4K4HTR7 | |
| SCHEMBL21593091 | 0.73 | HTR7 (0.58) | NUDT1MAP4K4HTR7 | |
| SCHEMBL9788711 | 0.73 | NUDT1 (0.54) | ALDH1A1NUDT1MAP4K4KCNN3HTR7 | |
| SCHEMBL1678955 | 0.73 | CSF1R (0.62) | NUDT1KCNN3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117884-B2 | Potent gamma-secretase modulators | THE GENERAL HOSPITAL CORPORATION (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200055840-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-20 | — | — | US | disclosed |
| US-10472346-B2 | Potent gamma-secretase modulators | THE GENERAL HOSPITAL CORPORATION (US) | 2019-11-12 | — | — | US | disclosed |
| US-20180093967-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE GENERAL HOSPITAL CORPORATION | 2018-04-05 | — | — | US | disclosed |
| WO-2016070107-A1 | POTENT GAMMA-SECRETASE MODULATORS | THE GENERAL HOSPITAL CORPORATION (US) | 2016-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200055840-A1 | POTENT GAMMA-SECRETASE MODULATORS | BACE1, BACE2, GSAP | ALDH1A1 2818/4885NUDT1 4091/4885GAA 28/4885 |
| US-10472346-B2 | Potent gamma-secretase modulators | BACE1, BACE2, APP | ALDH1A1 2207/4885NUDT1 4482/4885GAA 264/4885 |
| US-11117884-B2 | Potent gamma-secretase modulators | BACE1, BACE2, GSAP | ALDH1A1 2818/4885NUDT1 4091/4885GAA 28/4885 |
| US-20180093967-A1 | POTENT GAMMA-SECRETASE MODULATORS | BACE1, BACE2, APP | ALDH1A1 2207/4885NUDT1 4482/4885GAA 264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.