Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SCN1A | P35498 | 8/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 8/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 5/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17723376 | 0.78 | ALDH1A1 (0.51) | ALDH1A1GAAMAPTMAP4K4 | |
| SCHEMBL8051390 | 0.75 | GPR55 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8038836 | 0.74 | NPC1 (0.48) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL12411080 | 0.73 | GAA (0.54) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL15247585 | 0.70 | MAPKAPK2 (0.44) | MAPKAPK2ALDH1A1GAAMAPTTNF | |
| SCHEMBL30923599 | 0.69 | MAPKAPK2 (0.51) | MAPKAPK2SCN1ASCN5ASCN8ASCN1B | |
| SCHEMBL10094181 | 0.69 | ALDH1A1 (0.53) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL8038833 | 0.69 | PDE2A (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28860236 | 0.68 | SCN1A (0.44) | SCN1ASCN5ASCN8ASCN1BTNF | |
| SCHEMBL11849300 | 0.67 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009050227-A1 | PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION | GLAXO GROUP LIMITED (GB) | 2009-04-23 | — | — | WO | disclosed |