Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ARG1 | P05089 | 3/20 | 0.36 |
| ▸ | ARG2 | P78540 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039102 | 1.00 | GSR (0.53) | GSRTHRBALOX5KMT2APOLB | |
| 5-Methylfurfural SCHEMBL8037619 | 0.85 | ALOX5 (0.43) | ALOX5KMT2APOLBTDP1ALDH1A1 | |
| 5-Methylfurfural SCHEMBL8037614 | 0.85 | ALOX5 (0.43) | ALOX5KMT2APOLBTDP1ALDH1A1 | |
| Lysine SCHEMBL8036020 | 0.77 | GSR (0.57) | GSRTHRBKMT2APOLBTDP1 | |
| Lysine SCHEMBL8036023 | 0.77 | GSR (0.57) | GSRTHRBKMT2APOLBTDP1 | |
| 5-Methylfurfural SCHEMBL7792249 | 0.77 | ALDH1A1 (0.47) | ALOX5KMT2APOLBTDP1ALDH1A1 | |
| Lysine SCHEMBL1043432 | 0.75 | GSR (0.80) | GSRKMT2AMEN1ARG1ARG2 | |
| Lysine SCHEMBL9547128 | 0.75 | GSR (0.80) | GSRKMT2AMEN1ARG1ARG2 | |
| Lysine SCHEMBL16879745 | 0.74 | GSR (0.67) | GSRTHRBKMT2APOLBTDP1 | |
| Lysine SCHEMBL93725 | 0.73 | GSR (0.77) | GSRARG1ARG2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |