Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028301 | 0.86 | APP (0.39) | APPLRRK2S1PR1GAALMNA | |
| SCHEMBL8041698 | 0.85 | CYP1A2 (0.41) | APPLRRK2S1PR1GAALMNA | |
| SCHEMBL8035717 | 0.83 | ALDH1A1 (0.45) | S1PR1GAALMNAMAPT | |
| SCHEMBL8035586 | 0.81 | SMPD1 (0.45) | APPRBP4 | |
| SCHEMBL8037833 | 0.81 | SMO (0.39) | APPLRRK2S1PR1LMNAMAPT | |
| SCHEMBL8038215 | 0.80 | S1PR1 (0.40) | APPLRRK2S1PR1GAALMNA | |
| SCHEMBL8037415 | 0.79 | S1PR1 (0.41) | APPS1PR1GAA | |
| SCHEMBL8037366 | 0.79 | S1PR1 (0.41) | APPS1PR1GAALMNAMAPT | |
| SCHEMBL8033842 | 0.78 | RAB9A (0.42) | S1PR1MAPT | |
| SCHEMBL8037435 | 0.77 | PDE10A (0.41) | APPS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081892-A1 | NOVEL CATECHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USE OF THOSE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |