Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033764 | 0.88 | HTT (0.46) | CYP2C19ALDH1A1LMNAUSP2HCAR2 | |
| SCHEMBL8042788 | 0.85 | HSD17B10 (0.42) | CYP2C19ALDH1A1SMN1; SMN2HSD17B10HCAR2 | |
| SCHEMBL8043875 | 0.85 | UBE2M (0.37) | ALDH1A1HCAR2RXRARXRBRXRG | |
| SCHEMBL8042980 | 0.83 | ALDH1A1 (0.41) | CYP2C19ALDH1A1TP53SMN1; SMN2LMNA | |
| SCHEMBL8032986 | 0.82 | RXRA (0.34) | CYP2C19CYP2C9ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8714264 | 0.81 | CYP2C19 (0.43) | CYP2C19CYP2C9ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8041806 | 0.80 | KMT2A (0.38) | ALDH1A1TP53LMNAHSD17B10HCAR2 | |
| SCHEMBL8044040 | 0.80 | MAPK8 (0.52) | CYP2C19CYP2C9ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8050397 | 0.79 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2LMNARXRARXRB | |
| SCHEMBL8033751 | 0.79 | RXRA (0.43) | ALDH1A1TP53SMN1; SMN2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |