Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 15/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 15/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033764 | 0.88 | HTT (0.46) | HTTHCAR2RXRARXRBRXRG | |
| SCHEMBL8042788 | 0.85 | HSD17B10 (0.42) | HTTHCAR2RXRARXRBRXRG | |
| SCHEMBL8716288 | 0.85 | CYP2C19 (0.47) | HTTHCAR2RXRARXRBRXRG | |
| SCHEMBL8042980 | 0.83 | ALDH1A1 (0.41) | HTTHCAR2RXRARXRBRXRG | |
| SCHEMBL8032986 | 0.82 | RXRA (0.34) | HTTHCAR2RXRARXRBRXRG | |
| SCHEMBL8043225 | 0.82 | DCUN1D1 (0.39) | UBE2MDCUN1D1 | |
| SCHEMBL8052603 | 0.81 | DCUN1D1 (0.37) | UBE2MDCUN1D1HTT | |
| SCHEMBL8041806 | 0.80 | KMT2A (0.38) | HCAR2RXRARXRBRXRGALDH1A1 | |
| SCHEMBL8032939 | 0.80 | NPC1 (0.47) | UBE2MDCUN1D1HTTALDH1A1MAPT | |
| SCHEMBL8042742 | 0.80 | ALDH1A1 (0.39) | UBE2MDCUN1D1HTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |