Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042593 | 0.90 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8033927 | 0.84 | NPSR1 (0.40) | ALDH1A1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8043580 | 0.82 | HTT (0.43) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8033786 | 0.82 | MAPT (0.39) | ALDH1A1KMT2ATSHRLMNAHPGD | |
| SCHEMBL8033964 | 0.82 | SMN1; SMN2 (0.39) | ALDH1A1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8043982 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8048326 | 0.81 | TP53 (0.37) | ALDH1A1MEN1KMT2ARAB9APOLB | |
| SCHEMBL8051135 | 0.80 | L3MBTL1 (0.39) | ALDH1A1TSHRLMNAPOLBGAA | |
| SCHEMBL8043236 | 0.80 | UBE2M (0.35) | ALDH1A1HTT | |
| SCHEMBL8051249 | 0.79 | RAB9A (0.35) | ALDH1A1LMNARAB9APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |