Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033927 | 0.93 | NPSR1 (0.40) | HTTCYP2C19KMT2AMEN1ALDH1A1 | |
| SCHEMBL8033964 | 0.89 | SMN1; SMN2 (0.39) | HTTCYP2C19KMT2AMEN1ALDH1A1 | |
| SCHEMBL8043236 | 0.89 | UBE2M (0.35) | HTTALDH1A1 | |
| SCHEMBL8034114 | 0.86 | HTT (0.31) | HTTCYP2C19ALDH1A1 | |
| SCHEMBL8033786 | 0.84 | MAPT (0.39) | KMT2AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL8051249 | 0.84 | RAB9A (0.35) | HTTALDH1A1GAAPOLBHPGD | |
| SCHEMBL8042294 | 0.82 | ALDH1A1 (0.38) | HTTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8043035 | 0.80 | MAPT (0.33) | ALDH1A1POLBMAPTLMNA | |
| SCHEMBL8042982 | 0.80 | KMT2A (0.35) | HTTCYP2C19KMT2AMEN1ALDH1A1 | |
| SCHEMBL8042593 | 0.80 | ALDH1A1 (0.47) | HTTKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |