Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29020377 | 0.77 | SLC6A2 (0.30) | — | |
| SCHEMBL394425 | 0.77 | RIPK1 (0.33) | LMNARIPK1 | |
| SCHEMBL27337058 | 0.73 | SLC6A2 (0.48) | — | |
| SCHEMBL2698490 | 0.73 | SLC6A2 (0.30) | — | |
| SCHEMBL15983796 | 0.72 | LMNA (0.49) | LMNAPOLBPTGES2PPARAHIF1A | |
| SCHEMBL517462 | 0.72 | SMN1; SMN2 (0.57) | LMNAPPARAHIF1ASMN1; SMN2CYP2C19 | |
| SCHEMBL28031572 | 0.72 | ALDH1A1 (0.37) | CYP2C19CYP2C9 | |
| SCHEMBL6893898 | 0.72 | — | — | |
| SCHEMBL1521437 | 0.71 | AKR1B1 (0.48) | LMNAKDM4ETSHR | |
| SCHEMBL28727407 | 0.71 | SMN1; SMN2 (0.55) | LMNAPPARAHIF1ASMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060475-A | Substituted pyrazin-2-yl-sulphonamide-(3-pyridyl) compounds and uses thereof | ZENECA LIMITED (GB) | 2000-05-09 | — | — | US | claimed |