Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042500 | 0.83 | KDM4E (0.38) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8050159 | 0.76 | LMNA (0.42) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8044154 | 0.76 | SMN1; SMN2 (0.43) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8044821 | 0.75 | ALDH1A1 (0.47) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8041927 | 0.74 | TP53 (0.47) | HTTSMN1; SMN2ALDH1A1HPGDLMNA | |
| SCHEMBL8050073 | 0.74 | GPR84 (0.41) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8044158 | 0.74 | TSHR (0.54) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8046872 | 0.74 | RPA1 (0.52) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8042069 | 0.74 | LMNA (0.40) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL8045447 | 0.70 | POLA1 (0.41) | HTTNPSR1SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |