Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 2/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044812 | 0.89 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8044092 | 0.89 | KMT2A (0.45) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8046294 | 0.86 | UBE2M (0.45) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8034319 | 0.85 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8044654 | 0.85 | MAPT (0.44) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8042159 | 0.84 | RAB9A (0.47) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8045514 | 0.83 | HPGD (0.54) | ALDH1A1LMNASMN1; SMN2HTTMAPK1 | |
| SCHEMBL8050838 | 0.83 | KDM4E (0.36) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8042731 | 0.82 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2HTTTP53 | |
| SCHEMBL8041897 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |