Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042528 | 0.89 | ALDH1A1 (0.45) | KMT2ALMNAHSD17B10TP53MAPT | |
| SCHEMBL8033588 | 0.87 | HSD17B10 (0.45) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8041897 | 0.86 | ALDH1A1 (0.47) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8049946 | 0.86 | ALOX5 (0.47) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8048028 | 0.86 | KMT2A (0.44) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8044888 | 0.83 | MEN1 (0.53) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8050817 | 0.82 | PTGS2 (0.57) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8050838 | 0.81 | KDM4E (0.36) | KMT2ALMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL8042731 | 0.80 | ALDH1A1 (0.41) | KMT2ALMNAMEN1HSD17B10TP53 | |
| SCHEMBL8044564 | 0.80 | CYP19A1 (0.48) | KMT2ALMNAMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |