Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | LMNA | P02545 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 2/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048028 | 0.89 | KMT2A (0.44) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8044812 | 0.88 | ALDH1A1 (0.52) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8042528 | 0.85 | ALDH1A1 (0.45) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8046294 | 0.85 | UBE2M (0.45) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8034319 | 0.84 | ALDH1A1 (0.51) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8043941 | 0.83 | PTGS2 (0.37) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8042159 | 0.83 | RAB9A (0.47) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8042535 | 0.82 | PTGS2 (0.44) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8045514 | 0.82 | HPGD (0.54) | MAPTPOLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8041897 | 0.81 | ALDH1A1 (0.47) | MAPTPOLBALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |