Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042849 | 0.89 | ALDH1A1 (0.33) | SMN1; SMN2ALDH1A1NPC1TP53RAB9A | |
| SCHEMBL8046313 | 0.87 | ALDH1A1 (0.35) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8037025 | 0.81 | MEN1 (0.37) | — | |
| SCHEMBL8043914 | 0.80 | — | — | |
| SCHEMBL8045389 | 0.79 | RXRA (0.40) | TRPM8SMN1; SMN2ALDH1A1NPC1TP53 | |
| SCHEMBL8044714 | 0.78 | RAB9A (0.34) | SMN1; SMN2LMNAALDH1A1NPC1TP53 | |
| SCHEMBL8044450 | 0.78 | MAPK8 (0.52) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL8045169 | 0.77 | — | — | |
| SCHEMBL8050943 | 0.74 | FBP1 (0.42) | TRPM8SMN1; SMN2LMNA | |
| SCHEMBL8710115 | 0.72 | FBP1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |