Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | SELE | P16581 | 2/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043004 | 0.88 | MAPK8 (0.39) | MAPK8MAPK9KMT2AALDH1A1NPSR1 | |
| SCHEMBL8044324 | 0.86 | ALDH1A1 (0.37) | MAPK8MAPK9ALDH1A1MAPK10 | |
| SCHEMBL8043957 | 0.84 | MAPK8 (0.33) | MAPK8MAPK9MAPK10USP7 | |
| SCHEMBL8051775 | 0.83 | POLB (0.40) | MAPK8MAPK9KMT2AMEN1KDM4E | |
| SCHEMBL8044265 | 0.81 | MAPK8 (0.32) | MAPK8MAPK9MAPK10 | |
| SCHEMBL8044476 | 0.79 | MAPK8 (0.33) | MAPK8MAPK9RAB9AMAPTPKM | |
| SCHEMBL8042807 | 0.79 | MEN1 (0.44) | KMT2AMEN1ALDH1A1NPSR1RAB9A | |
| SCHEMBL8043836 | 0.78 | ICAM1 (0.40) | MAPK8MAPK9ALDH1A1RAB9AMAPT | |
| SCHEMBL8034054 | 0.78 | F2 (0.44) | MAPK8MAPK9ALDH1A1RAB9AMAPK10 | |
| SCHEMBL8034366 | 0.78 | ALDH1A1 (0.45) | KMT2AMEN1KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |