Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | RHOA | P61586 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10283486 | 0.91 | HDAC1 (0.39) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL792958 | 0.77 | ALDH1A1 (0.35) | SCN9AALDH1A1KDM4EPOLBGAA | |
| SCHEMBL792698 | 0.75 | MET (0.38) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL2273051 | 0.73 | PRKCA (0.48) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL2272974 | 0.72 | PRKCA (0.48) | CYP3A4CYP2C19CYP2C9ALDH1A1NR1I2 | |
| SCHEMBL1260089 | 0.72 | CYP3A4 (0.59) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL4809086 | 0.71 | CYP3A4 (0.59) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL2276602 | 0.70 | PARP1 (0.41) | ALDH1A1KDM4EGAAMCHR1MAPT | |
| SCHEMBL12429233 | 0.69 | PRKCA (0.48) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A | |
| SCHEMBL2875194 | 0.69 | SCN9A (0.48) | CYP3A4CYP2C19CYP2C9CYP2D6SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | POLI, TERT, ZC3HAV1 | CYP3A4 1341/4885CYP2C19 1316/4885CYP2C9 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.