Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.44 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11909339 | 0.81 | HPGD (0.45) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL8045110 | 0.81 | SIGMAR1 (0.57) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL22549684 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL19429591 | 0.76 | ALDH1A1 (0.64) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL17551490 | 0.76 | ALDH1A1 (0.64) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL19766518 | 0.76 | HSD11B1 (0.45) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL7365311 | 0.75 | CHRNB2 (0.57) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL10559542 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL20186941 | 0.74 | HPGD (1.00) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 | |
| SCHEMBL19612780 | 0.74 | HPGD (1.00) | ALDH1A1TSHRHPGDSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |