Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ATP4A | P20648 | 6/20 | 0.40 |
| ▸ | ATP4B | P51164 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034092 | 0.93 | HTR1A (0.49) | HTR1AHTR2AHTR7RAB9ANPC1 | |
| SCHEMBL8051868 | 0.89 | HTR1A (0.52) | HTR1AHTR2AHTR7RAB9ANPC1 | |
| SCHEMBL8044338 | 0.88 | POLB (0.44) | RAB9ANPC1MAPTALDH1A1HTT | |
| SCHEMBL8048789 | 0.84 | HTR1A (0.45) | HTR1AHTR2AHTR7RAB9ANPC1 | |
| SCHEMBL8042296 | 0.82 | RAB9A (0.39) | RAB9ANPC1MAPTALDH1A1KMT2A | |
| SCHEMBL8042378 | 0.82 | HTR1A (0.47) | HTR1AHTR2AHTR7RAB9ANPC1 | |
| SCHEMBL8050186 | 0.81 | ATP4A (0.35) | RAB9AMAPTALDH1A1TDP1KMT2A | |
| SCHEMBL8032624 | 0.81 | RAB9A (0.49) | HTR1AHTR2AHTR7RAB9ANPC1 | |
| SCHEMBL8044982 | 0.81 | MAPT (0.44) | RAB9ANPC1MAPTALDH1A1HTT | |
| SCHEMBL8047618 | 0.79 | RAB9A (0.46) | HTR1AHTR2AHTR7RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |