Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033941 | 0.92 | SMN1; SMN2 (0.36) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8043900 | 0.87 | SMN1; SMN2 (0.36) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8043683 | 0.82 | HTR1A (0.47) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8044623 | 0.80 | RAB9A (0.37) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8044338 | 0.80 | POLB (0.44) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8042050 | 0.80 | LMNA (0.42) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8045034 | 0.79 | RAB9A (0.41) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8050186 | 0.78 | ATP4A (0.35) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8044818 | 0.78 | RAB9A (0.41) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL8050096 | 0.78 | RAB9A (0.37) | RAB9ASMN1; SMN2KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |