Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042670 | 0.87 | RAB9A (0.43) | RAB9AHTTNPC1TDP1MAPT | |
| SCHEMBL8042378 | 0.82 | HTR1A (0.47) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8046620 | 0.82 | RAB9A (0.44) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8051868 | 0.81 | HTR1A (0.52) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8044448 | 0.79 | RAB9A (0.32) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL8034092 | 0.78 | HTR1A (0.49) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8032624 | 0.76 | RAB9A (0.49) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8043683 | 0.76 | HTR1A (0.47) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8032494 | 0.75 | HTR1A (0.43) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8045654 | 0.75 | ALDH1A1 (0.47) | HTR1AHTR2AHTR7RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |