Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050096 | 0.80 | RAB9A (0.37) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8043826 | 0.79 | HTR1A (0.44) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL8042936 | 0.79 | RAB9A (0.32) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8042670 | 0.77 | RAB9A (0.43) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8043900 | 0.77 | SMN1; SMN2 (0.36) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8050950 | 0.76 | FBP1 (0.39) | — | |
| SCHEMBL8033941 | 0.74 | SMN1; SMN2 (0.36) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8045500 | 0.72 | — | — | |
| SCHEMBL8045654 | 0.71 | ALDH1A1 (0.47) | RAB9ANPC1POLBGAASMN1; SMN2 | |
| SCHEMBL8042296 | 0.71 | RAB9A (0.39) | RAB9ANPC1POLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |