Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | SELE | P16581 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042105 | 0.79 | MAPK8 (0.56) | ICAM1SELEVCAM1GAAL3MBTL1 | |
| SCHEMBL8043915 | 0.78 | MAPK8 (0.37) | ICAM1SELEVCAM1MAPTPKM | |
| SCHEMBL8034033 | 0.78 | ALDH1A1 (0.36) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPK8 | |
| SCHEMBL8042630 | 0.78 | RAB9A (0.35) | ALDH1A1NPC1RAB9AMAPK8MAPK9 | |
| SCHEMBL8043004 | 0.76 | MAPK8 (0.39) | GAAMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL8043957 | 0.75 | MAPK8 (0.33) | MAPK8MAPK9MAPK10USP7 | |
| SCHEMBL8048020 | 0.75 | HCAR2 (0.56) | ICAM1SELEVCAM1GAAL3MBTL1 | |
| SCHEMBL8051775 | 0.74 | POLB (0.40) | GAAALDH1A1NPC1RAB9ACYP1A2 | |
| SCHEMBL8044324 | 0.74 | ALDH1A1 (0.37) | ALDH1A1MAPK8MAPK9MAPK10 | |
| SCHEMBL8043593 | 0.73 | ICAM1 (0.37) | ICAM1SELEVCAM1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |