Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043836 | 0.78 | ICAM1 (0.40) | ALDH1A1SMN1; SMN2MAPK8MAPK9MAPK10 | |
| SCHEMBL8047234 | 0.76 | RXRA (0.43) | ALDH1A1SMN1; SMN2MAPK1MAPK8MAPK9 | |
| SCHEMBL8043833 | 0.76 | MAPK8 (0.34) | ALDH1A1SMN1; SMN2MAPK1MAPK8MAPK9 | |
| SCHEMBL8042105 | 0.75 | MAPK8 (0.56) | ALDH1A1SMN1; SMN2MAPK1MAPK8MAPK9 | |
| SCHEMBL8042630 | 0.74 | RAB9A (0.35) | ALDH1A1MAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8043915 | 0.74 | MAPK8 (0.37) | ALDH1A1MAPK8MAPK9MAPK10NPC1 | |
| SCHEMBL8047678 | 0.72 | FBP1 (0.42) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL8043004 | 0.72 | MAPK8 (0.39) | ALDH1A1SMN1; SMN2MAPK8MAPK9MAPK10 | |
| SCHEMBL8043957 | 0.71 | MAPK8 (0.33) | MAPK8MAPK9MAPK10USP7 | |
| SCHEMBL8051775 | 0.71 | POLB (0.40) | ALDH1A1SMN1; SMN2MAPK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |