Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043945 | 0.86 | ALDH1A1 (0.57) | TDP1HSD17B10GAAALDH1A1LMNA | |
| SCHEMBL8044443 | 0.82 | ALDH1A1 (0.49) | TDP1POLBHSD17B10ALDH1A1LMNA | |
| SCHEMBL8033935 | 0.80 | HSD17B10 (0.47) | TDP1POLBHSD17B10GAACYP2A6 | |
| SCHEMBL8044564 | 0.80 | CYP19A1 (0.48) | POLBHSD17B10CYP3A4ALDH1A1LMNA | |
| SCHEMBL8042328 | 0.79 | HSD17B10 (0.48) | TDP1POLBHSD17B10CYP3A4GAA | |
| SCHEMBL8044963 | 0.79 | ALDH1A1 (0.42) | TDP1POLBHSD17B10CYP3A4GAA | |
| SCHEMBL8042731 | 0.78 | ALDH1A1 (0.41) | TDP1POLBHSD17B10GAAALDH1A1 | |
| SCHEMBL8044064 | 0.77 | ALDH1A1 (0.41) | TDP1POLBHSD17B10CYP3A4GAA | |
| SCHEMBL8045341 | 0.77 | ALDH1A1 (0.49) | HSD17B10GAAALDH1A1LMNAHTT | |
| SCHEMBL8046282 | 0.77 | SMN1; SMN2 (0.49) | POLBHSD17B10CYP3A4GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |