Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044564 | 0.90 | CYP19A1 (0.48) | ALDH1A1RAB9AKDM4EL3MBTL1CYP19A1 | |
| SCHEMBL8044812 | 0.89 | ALDH1A1 (0.52) | ALDH1A1RAB9AKDM4EL3MBTL1UBE2M | |
| SCHEMBL8043675 | 0.84 | KIT (0.39) | ALDH1A1KDM4EL3MBTL1CYP19A1TDP1 | |
| SCHEMBL8043953 | 0.82 | TDP1 (0.47) | ALDH1A1L3MBTL1LMNASMN1; SMN2TSHR | |
| SCHEMBL8046294 | 0.81 | UBE2M (0.45) | ALDH1A1RAB9AKDM4EL3MBTL1UBE2M | |
| SCHEMBL8041897 | 0.81 | ALDH1A1 (0.47) | ALDH1A1UBE2MDCUN1D1LMNASMN1; SMN2 | |
| SCHEMBL8042159 | 0.80 | RAB9A (0.47) | ALDH1A1RAB9AKDM4EL3MBTL1NPC1 | |
| SCHEMBL8042528 | 0.80 | ALDH1A1 (0.45) | ALDH1A1RAB9AL3MBTL1NPC1UBE2M | |
| SCHEMBL8044654 | 0.79 | MAPT (0.44) | ALDH1A1RAB9AKDM4ENPC1UBE2M | |
| SCHEMBL8034319 | 0.79 | ALDH1A1 (0.51) | ALDH1A1RAB9AKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |