Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 2/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042823 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP2C19LMNASMN1; SMN2RAB9A | |
| SCHEMBL8044019 | 0.83 | KMT2A (0.40) | ALDH1A1CYP2C9CYP2C19LMNASMN1; SMN2 | |
| SCHEMBL8042045 | 0.82 | UBE2M (0.46) | UBE2MDCUN1D1 | |
| SCHEMBL8033682 | 0.82 | RAB9A (0.45) | ALDH1A1TP53CYP2C9CYP2C19LMNA | |
| SCHEMBL8710280 | 0.80 | CYP2C9 (0.44) | ALDH1A1TP53CYP2C9CYP2C19LMNA | |
| SCHEMBL8032462 | 0.80 | CYP2C19 (0.39) | ALDH1A1TP53CYP2C9CYP2C19LMNA | |
| SCHEMBL8032361 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TP53LMNASMN1; SMN2RAB9A | |
| SCHEMBL8033073 | 0.79 | RAB9A (0.36) | ALDH1A1TP53LMNASMN1; SMN2RAB9A | |
| SCHEMBL8047810 | 0.78 | CYP2C9 (0.37) | ALDH1A1TP53CYP2C9CYP2C19LMNA | |
| SCHEMBL8720492 | 0.77 | RAB9A (0.41) | ALDH1A1TP53CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |