Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043030 | 0.86 | HTT (0.42) | CYP2C19ALDH1A1LMNAUSP2KMT2A | |
| SCHEMBL8045352 | 0.83 | ALOX15 (0.41) | ALDH1A1LMNASMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL8045829 | 0.82 | HTR7 (0.47) | KDM1ALMNAKMT2ANPSR1HTR7 | |
| SCHEMBL8043987 | 0.80 | ALDH1A1 (0.45) | CYP2C9CYP2C19ALDH1A1TP53LMNA | |
| SCHEMBL8042471 | 0.80 | ALDH1A1 (0.47) | CYP2C19KDM1AALDH1A1TP53LMNA | |
| SCHEMBL8044130 | 0.79 | NPSR1 (0.33) | KDM1ATP53LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8714264 | 0.75 | CYP2C19 (0.43) | CYP2C9CYP2C19ALDH1A1TP53LMNA | |
| SCHEMBL8038016 | 0.75 | HTT (0.46) | ALDH1A1TP53LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL8032420 | 0.75 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2HSD17B10USP2 | |
| SCHEMBL8716288 | 0.75 | CYP2C19 (0.47) | CYP2C9CYP2C19ALDH1A1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |