Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 3/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044019 | 0.92 | KMT2A (0.40) | ALDH1A1LMNAMAPTCYP2C19KMT2A | |
| SCHEMBL8032361 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HTTLMNAMAPTUSP2 | |
| SCHEMBL8043987 | 0.86 | ALDH1A1 (0.45) | ALDH1A1LMNAUSP2CYP2C19KMT2A | |
| SCHEMBL8042045 | 0.86 | UBE2M (0.46) | UBE2MDCUN1D1 | |
| SCHEMBL8033073 | 0.82 | RAB9A (0.36) | ALDH1A1HTTLMNAMAPTUSP2 | |
| SCHEMBL8033580 | 0.80 | POLB (0.44) | ALDH1A1HTTLMNAMAPTUSP2 | |
| SCHEMBL8033559 | 0.80 | LMNA (0.47) | ALDH1A1HTTLMNAMAPTTSHR | |
| SCHEMBL8044066 | 0.79 | HTT (0.45) | ALDH1A1HTTLMNAMAPTUSP2 | |
| SCHEMBL8046481 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HTTLMNAMAPTUSP2 | |
| SCHEMBL8043030 | 0.78 | HTT (0.42) | ALDH1A1HTTLMNAMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |