Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034012 | 0.85 | LTA4H (0.37) | MAPTALOX5F2RL3EIF4EICAM1 | |
| SCHEMBL8051771 | 0.85 | ALOX5 (0.36) | MAPTALOX5F2RL3RAB9AEIF4E | |
| SCHEMBL8043997 | 0.85 | MAPT (0.35) | MAPTALOX5F2RL3NPC1RAB9A | |
| SCHEMBL8044824 | 0.84 | MAPT (0.34) | MAPTALOX5F2RL3EIF4EKMT2A | |
| SCHEMBL8046557 | 0.84 | CTSS (0.35) | MAPTALOX5F2RL3EIF4EKMT2A | |
| SCHEMBL8048125 | 0.82 | CTSK (0.41) | MAPTALOX5F2RL3NPC1RAB9A | |
| SCHEMBL8033655 | 0.81 | EIF4E (0.34) | MAPTALOX5F2RL3EIF4EKMT2A | |
| SCHEMBL8050843 | 0.81 | CTSS (0.38) | MAPTALOX5F2RL3EIF4ECTSS | |
| SCHEMBL8048151 | 0.81 | F2RL3 (0.37) | MAPTALOX5F2RL3RAB9ALMNA | |
| SCHEMBL8052850 | 0.80 | KMT2A (0.43) | ALOX5RAB9AEIF4EKMT2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |