Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.57 |
| ▸ | CA1 | P00915 | 5/20 | 0.50 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043233 | 0.90 | PTGS2 (0.56) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8033669 | 0.84 | KDM1A (0.51) | PTGS2MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8033588 | 0.84 | HSD17B10 (0.45) | PTGS2MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8041897 | 0.84 | ALDH1A1 (0.47) | MEN1LMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8044888 | 0.82 | MEN1 (0.53) | PTGS2CA1CA2MEN1LMNA | |
| SCHEMBL8043931 | 0.82 | PTGS2 (0.43) | PTGS2CA1CA2CA9CA12 | |
| SCHEMBL8044092 | 0.82 | KMT2A (0.45) | PTGS2MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8049946 | 0.81 | ALOX5 (0.47) | PTGS2MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8048028 | 0.81 | KMT2A (0.44) | PTGS2MEN1LMNACYP1A2CYP3A4 | |
| SCHEMBL8032472 | 0.81 | PTGS2 (0.48) | PTGS2CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |