Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.59 |
| ▸ | BMP1 | P13497 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794166 | 0.79 | MMP3 (0.69) | MMP3BMP1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8039632 | 0.76 | MMP3 (0.57) | MMP3BMP1 | |
| SCHEMBL8038079 | 0.75 | MMP3 (0.53) | MMP3BMP1CYP2C19ALDH1A1KMT2A | |
| SCHEMBL7918690 | 0.75 | CA1 (0.60) | MMP3RORCALDH1A1KMT2AMEN1 | |
| SCHEMBL7350845 | 0.74 | MMP3 (1.00) | MMP3BMP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8038065 | 0.73 | CNR2 (0.59) | MMP3BMP1KMT2AMEN1 | |
| SCHEMBL8041116 | 0.73 | MMP2 (0.55) | MMP3RORCKMT2AMEN1 | |
| SCHEMBL8037741 | 0.73 | CNR2 (0.59) | MMP3BMP1KMT2AMEN1 | |
| SCHEMBL6843429 | 0.73 | CNR2 (0.59) | MMP3BMP1KMT2AMEN1 | |
| SCHEMBL6795800 | 0.72 | BMP1 (0.69) | MMP3BMP1LMNACYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124329-A | AN ENZYME INHIBITOR FOR THE TREATMENT OR PROPHYLAXIS OF TISSUE BREAKDOWN, FOR EXAMPLE RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR, MULTIPLE SCLEROSIS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0766664-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-04-05 | — | — | EP | disclosed |
| EP-0766664-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035275-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |