Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045211 | 0.89 | KMT2A (0.48) | MAPTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8047523 | 0.89 | PARP1 (0.53) | PARP1RECQLMAPTTDP1HSD17B10 | |
| SCHEMBL8043462 | 0.85 | RAB9A (0.47) | MAPTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8043684 | 0.83 | RAB9A (0.48) | MAPTTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL8046042 | 0.83 | SMN1; SMN2 (0.46) | MAPTHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL8048108 | 0.83 | KMT2A (0.40) | MAPTTDP1HSD17B10ALDH1A1KMT2A | |
| SCHEMBL8033209 | 0.81 | HTR1A (0.49) | RECQLMAPTTDP1ALDH1A1KMT2A | |
| SCHEMBL8048077 | 0.80 | MAPT (0.51) | RECQLMAPTTDP1HSD17B10ALDH1A1 | |
| SCHEMBL8042404 | 0.79 | MAPT (0.45) | PARP1RECQLMAPTTDP1ALDH1A1 | |
| SCHEMBL8050659 | 0.79 | RAB9A (0.48) | MAPTTDP1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |