Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042404 | 0.90 | MAPT (0.45) | KMT2AMEN1MAPTLMNATSHR | |
| SCHEMBL8044267 | 0.89 | PARP1 (0.49) | KMT2AMEN1MAPTLMNATSHR | |
| SCHEMBL8047850 | 0.85 | MEN1 (0.44) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL8042084 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL8042990 | 0.82 | RAB9A (0.47) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL13731275 | 0.82 | L3MBTL1 (0.60) | KMT2AMEN1MAPTLMNATSHR | |
| SCHEMBL8046042 | 0.81 | SMN1; SMN2 (0.46) | KMT2AMEN1MAPTTSHRRAB9A | |
| SCHEMBL8048108 | 0.81 | KMT2A (0.40) | KMT2AMEN1MAPTTDP1L3MBTL1 | |
| SCHEMBL8032967 | 0.80 | RAB9A (0.48) | KMT2AMEN1MAPTLMNARAB9A | |
| SCHEMBL8032807 | 0.80 | MEN1 (0.45) | KMT2AMEN1MAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |