Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032345 | 0.77 | HSD17B10 (0.43) | ALDH1A1KDM4EHPGDHSD17B10NPC1 | |
| SCHEMBL8046719 | 0.77 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1KDM4EHPGDALOX15 | |
| SCHEMBL8051238 | 0.76 | HSD17B10 (0.42) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL8042994 | 0.75 | GABRA5 (0.41) | L3MBTL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8046056 | 0.75 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1KDM4EHPGDALOX15 | |
| SCHEMBL8044815 | 0.74 | GABRA5 (0.40) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL8043409 | 0.74 | HSD17B10 (0.43) | L3MBTL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8047610 | 0.74 | GAA (0.46) | L3MBTL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8051833 | 0.74 | POLB (0.54) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL8044541 | 0.74 | ALOX15 (0.41) | ALDH1A1HPGDALOX15HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |