Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.59 |
| ▸ | RAB9A | P51151 | 15/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.59 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL969040 | 0.79 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL46426 | 0.77 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL28353374 | 0.76 | ALDH1A1 (0.48) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL13801152 | 0.75 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL4343181 | 0.74 | NPC1 (0.94) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL522555 | 0.72 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL46424 | 0.72 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL74999 | 0.72 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL22858502 | 0.72 | NPC1 (0.90) | NPC1RAB9ASMN1; SMN2ATAD2HPGD | |
| SCHEMBL406885 | 0.71 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ATAD2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |