SCHEMBL74999

SCHEMBL74999

c1ccc(-c2ccc(-c3nnc(-c4ccc(-c5ccc(-c6nnc(-c7ccc(-c8ccccc8)cc7)o6)cc5)cc4)o3)cc2)cc1

nearest known ligand 0.90

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 15/20 0.90
RAB9A P51151 15/20 0.90
SMN1; SMN2 Q16637 9/20 0.90
HPGD P15428 7/20 0.79
ALDH1A1 P00352 5/20 0.79
KDM4E B2RXH2 4/20 0.79
HSD17B10 Q99714 2/20 0.79
GLA P06280 1/20 0.79
MAPT P10636 1/20 0.79
ALOX15 P16050 1/20 0.79
NFKB1 P19838 2/20 0.75
NFKB2 Q00653 2/20 0.75
RELA Q04206 2/20 0.75
POLB P06746 1/20 0.75
MEN1 O00255 1/20 0.75
KMT2A Q03164 1/20 0.75
ATAD2 Q6PL18 1/20 0.71
GAA P10253 1/20 0.68
CA1 P00915 2/20 0.66
CA2 P00918 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22858502 1.00 NPC1 (0.90) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL522555 1.00 NPC1 (0.90) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL46424 1.00 NPC1 (0.90) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL1105099 0.97 NPC1 (0.85) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL4343181 0.97 NPC1 (0.94) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL46426 0.95 NPC1 (1.00) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL12306750 0.91 NPC1 (0.74) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL12765574 0.91 RAB9A (0.76) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL12111793 0.91 NPC1 (0.74) NPC1RAB9ASMN1; SMN2HPGDALDH1A1
SCHEMBL19391492 0.91 NPC1 (0.74) NPC1RAB9ASMN1; SMN2HPGDALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 921 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12022728-B2 Organic electroluminescent element and electronic device IDEMITSU KOSAN CO., LTD. (JP) 2024-06-25 US disclosed
WO-2024126635-A1 FORMULATION OF AN ORGANIC FUNCTIONAL MATERIAL MERCK PATENT GMBH (DE) 2024-06-20 WO disclosed
EP-3475372-B1 FORMULATION OF AN ORGANIC FUNCTIONAL MATERIAL MERCK PATENT GMBH (DE) 2023-11-22 EP disclosed
EP-3387077-B1 FORMULATIONS CONTAINING KETONES COMPRISING NON-AROMATIC CYCLES MERCK PATENT GMBH (DE) 2023-10-18 EP disclosed
US-11770971-B2 Esters containing aromatic groups as solvents for organic electronic formulations MERCK PATENT GMBH (DE) 2023-09-26 US disclosed
US-11751472-B2 Aromatic amine derivative and elecroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2023-09-05 US disclosed
EP-3807367-B1 FORMULATION OF AN ORGANIC FUNCTIONAL MATERIAL MERCK PATENT GMBH (DE) 2023-07-19 EP disclosed
US-11691983-B2 Specifically substituted benzofuro- and benzothienoquinolines for organic light emitting diodes IDEMITSU KOSAN CO., LTD. (JP) 2023-07-04 US disclosed
US-11691983-B2 Specifically substituted benzofuro- and benzothienoquinolines for organic light emitting diodes IDEMITSU KOSAN CO., LTD. (JP) 2023-07-04 US disclosed
US-11678571-B2 Organic electroluminescent device using aryl amine derivative containing heterocycle IDEMITSU KOSAN CO., LTD. (JP) 2023-06-13 US disclosed
EP-1753268-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT HAVING TWO ELECTROLUMINESCENT LAYERS THROUGH ELECTRON BARRIER LAYER IDEMITSU KOSAN CO., LTD. (JP) 2007-02-14 EP disclosed
US-20070029927-A1 AROMATIC AMINE DERIVATIVES AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-02-08 US disclosed
US-20070029927-A1 AROMATIC AMINE DERIVATIVES AND ELECTROLUMINESCENCE DEVICE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-02-08 US disclosed
EP-1749809-A1 ASYMMETRIC PYRENE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME IDEMITSU KOSAN CO., LTD. (JP) 2007-02-07 EP disclosed
US-20070013296-A1 Biphenyl derivative, material for organic electroluminescence device, and organic electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2007-01-18 US disclosed
US-20070013296-A1 Biphenyl derivative, material for organic electroluminescence device, and organic electroluminescence device using the same IDEMITSU KOSAN CO., LTD. (JP) 2007-01-18 US disclosed
US-20070007882-A1 Organic electroluminescent device and display using same IDEMITSU KOSAN CO., LTD. (JP) 2007-01-11 US disclosed
US-20070007882-A1 Organic electroluminescent device and display using same IDEMITSU KOSAN CO., LTD. (JP) 2007-01-11 US disclosed
US-20070009760-A1 Coordination metal compound, material for organic electroluminescence device, material for luminescent coating formation and organic electroluminescence device INOUE TETSUYA 2007-01-11 US disclosed
US-20070009760-A1 Coordination metal compound, material for organic electroluminescence device, material for luminescent coating formation and organic electroluminescence device INOUE TETSUYA 2007-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11678571-B2 Organic electroluminescent device using aryl amine derivative containing heterocycle RPS17, RPS19, CDK17 NPC1 4654/4885RAB9A 1510/4885SMN1; SMN2 3088/4885
US-11751472-B2 Aromatic amine derivative and elecroluminescence device using the same ALK, ALKBH3, ACVRL1 NPC1 4823/4885RAB9A 3793/4885SMN1; SMN2 4137/4885
US-11691983-B2 Specifically substituted benzofuro- and benzothienoquinolines for organic light emitting diodes KCNQ2, KCNQ1, KCNQ4 NPC1 2663/4885RAB9A 2910/4885SMN1; SMN2 3638/4885
US-20070029927-A1 AROMATIC AMINE DERIVATIVES AND ELECTROLUMINESCENCE DEVICE USING THE SAME TYR, MAOA, MAOB NPC1 4616/4885RAB9A 2148/4885SMN1; SMN2 2845/4885
US-12022728-B2 Organic electroluminescent element and electronic device L1CAM, ESR1, LEF1 NPC1 1857/4885RAB9A 1517/4885SMN1; SMN2 1059/4885
US-20070013296-A1 Biphenyl derivative, material for organic electroluminescence device, and organic electroluminescence device using the same EED, BMI1, EBPL NPC1 4338/4885RAB9A 2778/4885SMN1; SMN2 3834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.